CBD Element

CBD and L-theanine

Sunday, February 14, 2021 • 4 minute read

CBD and L-theanine is a common combination in CBD health supplements. These natural substances are believed to work together to provide relaxation.

What is L-theanine?

L-theanine is an amino acid found in both green and black tea as well as fungi. It has been found to promote relaxation without drowsiness (1). L-theanine, from recent modern studies, has been shown to have some exciting benefits. It is also thought to be responsible for many of the health benefits tea drinkers experience.

Can you take CBD oil with L-theanine?

Yes CBD can be taken with L-theanine.

Dr Ed Rest CBD oil, one of our most popular CBD oils, contains a blend of CBD, L-theanine and L-tryptophan. So L-theanine and CBD oil do not interact with each other, but instead their benefits compliment each other.

How does L-theanine work?

L-theanine is believed to increase dopamine and serotonin production in the brain, it also increases relaxation by enhancing alpha wave activity in the brain (2). Our brains produce alpha waves during meditation and deep relaxation.

Why combine CBD and L-theanine?

Evidence suggests that CBD can reduce stress and anxiety. CBD dampens the sympathetic nervous system and activates the parasympathetic nervous system. The sympathetic nervous system stimulates our ‘fight or flight’ response. On the other hand, the parasympathetic nervous system is activated after a stressful situation to induce calm and bring stress levels down. CBD is thought to increase the activity of the GABA neurotransmitter which boosts the parasympathetic nervous system, helping to steer us towards calmer waters(3)(4).

Evidently, L-theanine and CBD complement each other by promoting relaxation.

L-theanine does not cause drowsiness so combining L-theanine with CBD provides a double dose of ‘calm’ without an unpleasant, groggy feeling.

Our CBD and L-theanine Combo pick

If you are looking to combine L-theanine and CBD, look no further than Dr Ed’s Rest range.

Dr Edward Jones is a Neuroscientist, with his research examining how our brain can be manipulated. Dr Jones discovered the benefits of terpenes and other natural compounds and the importance of the endocannabinoid system. Dr Ed’s Rest range combines L-theanine, L-tryptophan, and CBD to create a product which the purpose of generating deep relaxation.


1) Williams, J., Kellett, J., Roach, P., McKune, A., Mellor, D., Thomas, J. and Naumovski, N., 2021. L-Theanine As A Functional Food Additive: Its Role In Disease Prevention And Health Promotion. [online] Available at: https://www.mdpi.com/2306-5710/2/2/13/htm [Accessed 16 January 2021].

2) Adhikary, R. and Mandal, V., 2021. L -Theanine: A Potential Multifaceted Natural Bioactive Amide As Health Supplement. [online] Available at: https://www.sciencedirect.com/science/article/pii/S2221169117308420#:~:text=Mode%20of%20action%20of%20l%2Dtheanine&text=l%2Dtheanine%20increases%20dopamine%20and,alpha%20wave%20activity%20in%20brain. [Accessed 16 January 2021].

3) Banerjee, S., Snyder, S. and Mechoulam, R., 2021. Cannabinoids: Influence On Neurotransmitter Uptake In Rat Brain Synaptosomes.. [online] Journal of Pharmacology and Experimental Therapeutics. Available at: https://jpet.aspetjournals.org/content/194/1/74.short [Accessed 16 January 2021].

4) ResearchGate. 2021. (PDF) The Direct Actions Of Cannabidiol And 2-Arachidonoyl Glycerol At GABAA Receptors. [online] Available at: https://www.researchgate.net/publication/314109989_The_Direct_Actions_of_Cannabidiol_and_2-Arachidonoyl_Glycerol_at_GABAA_Receptors [Accessed 16 January 2021].